TY - JOUR
T1 - How does a protein search for the specific site on DNA
T2 - The role of disorder.
AU - Hu, Tao
AU - Shklovskii, B. I.
PY - 2006/8
Y1 - 2006/8
N2 - Proteins can locate their specific targets on DNA up to two orders of magnitude faster than the Smoluchowski three-dimensional diffusion rate. This happens due to nonspecific adsorption of proteins to DNA and subsequent one-dimensional sliding along DNA. We call such a one-dimensional route towards the target an "antenna." We studied the role of the dispersion of nonspecific binding energies within the antenna due to a quasirandom sequence of natural DNA. A random energy profile for sliding proteins slows the searching rate for the target. We show that this slowdown is different for macroscopic and mesoscopic antennas.
AB - Proteins can locate their specific targets on DNA up to two orders of magnitude faster than the Smoluchowski three-dimensional diffusion rate. This happens due to nonspecific adsorption of proteins to DNA and subsequent one-dimensional sliding along DNA. We call such a one-dimensional route towards the target an "antenna." We studied the role of the dispersion of nonspecific binding energies within the antenna due to a quasirandom sequence of natural DNA. A random energy profile for sliding proteins slows the searching rate for the target. We show that this slowdown is different for macroscopic and mesoscopic antennas.
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U2 - 10.1103/PhysRevE.74.021903
DO - 10.1103/PhysRevE.74.021903
M3 - Article
C2 - 17025468
AN - SCOPUS:33746786817
SN - 1539-3755
VL - 74
JO - Physical review. E, Statistical, nonlinear, and soft matter physics
JF - Physical review. E, Statistical, nonlinear, and soft matter physics
IS - 2 Pt 1
M1 - 021903
ER -