TY - JOUR
T1 - How well can new-generation density functionals describe protonated epoxides where older functionals fail?
AU - Zhao, Yan
AU - Truhlar, Donald G.
PY - 2007/1/5
Y1 - 2007/1/5
N2 - In a recent article, Carlier et al. (J. Org. Chem. 2006, 71, 1592) examined the prediction of several DFT functional and showed that the most popular density functional, B3LYP, and 15 others fail badly for the prediction of the structure of protonated 2-methyl-1,2-epoxypropane. In this note, we compare the performance of several recently developed density functionals for the calculation of structures and energetics of protonated cyclic ethers, including epoxides. We found that several of the newly developed DFT methods perform better than B3LYP or any of the other 17 functionals examined by Carlier. We conclude that a recently published functional, M05-2X, has greatly improved performance for an unsymmetrical protonated epoxide, and we recommend this functional for studies that involve protonated epoxides and protonated ethers.
AB - In a recent article, Carlier et al. (J. Org. Chem. 2006, 71, 1592) examined the prediction of several DFT functional and showed that the most popular density functional, B3LYP, and 15 others fail badly for the prediction of the structure of protonated 2-methyl-1,2-epoxypropane. In this note, we compare the performance of several recently developed density functionals for the calculation of structures and energetics of protonated cyclic ethers, including epoxides. We found that several of the newly developed DFT methods perform better than B3LYP or any of the other 17 functionals examined by Carlier. We conclude that a recently published functional, M05-2X, has greatly improved performance for an unsymmetrical protonated epoxide, and we recommend this functional for studies that involve protonated epoxides and protonated ethers.
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U2 - 10.1021/jo061863z
DO - 10.1021/jo061863z
M3 - Article
C2 - 17194116
AN - SCOPUS:33846115771
SN - 0022-3263
VL - 72
SP - 295
EP - 298
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 1
ER -