Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats

R. Paul Robertson; David J. Baylink

doi:10.1016/0090-6980(77)90140-X

Hypercalcemia induced by prostaglandin E₂ in thyroparathyroidectomized but not intact rats

R. Paul Robertson, David J. Baylink

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Prostaglandin E₂ was infused into the thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 ± 0.21 mg/dl (x ± SE, p<.001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE₂ infusion may have been due to calcitonin counterregulation.

Original language	English (US)
Pages (from-to)	1141-1145
Number of pages	5
Journal	Prostaglandins
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/0090-6980(77)90140-X
State	Published - Jun 1977
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported in part by Veterans Administration Research and Education Program (MRIS No. 7511) and NIH Grant HD-0482. Dr. Baylink (MRIS No. 0483) is a recipient of RCDA DE 19108. Reprint requests to R. Paul Robertson, M. D., Veterans Administration Hospital, 4435 Beacon Avenue South, Seattle, Washington 98108.

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title = "Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats",

abstract = "Prostaglandin E2 was infused into the thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 ± 0.21 mg/dl (x ± SE, p<.001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE2 infusion may have been due to calcitonin counterregulation.",

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note = "Funding Information: This work was supported in part by Veterans Administration Research and Education Program (MRIS No. 7511) and NIH Grant HD-0482. Dr. Baylink (MRIS No. 0483) is a recipient of RCDA DE 19108. Reprint requests to R. Paul Robertson, M. D., Veterans Administration Hospital, 4435 Beacon Avenue South, Seattle, Washington 98108.",

year = "1977",

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doi = "10.1016/0090-6980(77)90140-X",

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AU - Baylink, David J.

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N2 - Prostaglandin E2 was infused into the thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 ± 0.21 mg/dl (x ± SE, p<.001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE2 infusion may have been due to calcitonin counterregulation.

AB - Prostaglandin E2 was infused into the thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 ± 0.21 mg/dl (x ± SE, p<.001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE2 infusion may have been due to calcitonin counterregulation.

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