Abstract
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo- inositol may be a marker for cerebral pathology, although it has a well- known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health.
Original language | English (US) |
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Pages (from-to) | 313-316 |
Number of pages | 4 |
Journal | Magnetic resonance in medicine |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1998 |
Keywords
- Human brain
- Inositol phosphates
- Scyllo-inositol
- Spectroscopy