Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA

Medicine & Life Sciences

• Deoxyguanosine 100%
• Electrospray Ionization Mass Spectrometry 96%
• 1-Butanol 95%
• Liquid Chromatography 60%
• DNA 38%
• Hydrolysis 32%
• DNA Adducts 28%
• 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone 25%
• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol 20%
• Rodentia 19%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 17%
• Hot Temperature 17%
• Metabolic Activation 14%
• Hydroxylation 13%
• Microsomes 12%
• Tandem Mass Spectrometry 12%
• Carcinogens 11%
• Tobacco 10%
• Tobacco Products 10%
• Ions 9%
• High Pressure Liquid Chromatography 9%
• Carcinogenesis 8%
• Acids 8%
• Enzymes 6%

Chemical Compounds

• Adduct 49%
• Electrospray Ionization Mass Spectrometry 47%
• Liquid Chromatography 28%
• 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol 17%
• Metabolic Activation 12%
• Hydrolysis 12%
• Carcinogenic 10%
• Liquid Chromatography Mass Spectrometry (LCMS) 10%
• Electrospray Ionization Mass Spectroscopy 10%
• Acid Hydrolysis 9%
• Marker 8%
• Metabolite 6%
• Ion 3%