Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E

M. Houser; B. Zimmerman; M. Davidman; C. Smith; A. Sinaiko; A. Fish

doi:10.1038/ki.1984.152

Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E

M. Houser, B. Zimmerman, M. Davidman, C. Smith, A. Sinaiko, A. Fish

Pediatrics - Nephrology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A patient with idiopathic hypercalciuria and some features suggestive of Bartter syndrome is reported. Excessive urinary prostaglandin E (PGE) excretion and renal calcium leak were documented in this child. Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion. At the lowest levels of urinary PGE, the renal calcium leak was no longer evident although mild hypercalciuria persisted. These results suggest that PGE may play a role in some cases of idiopathic hypercalciuria.

Original language	English (US)
Pages (from-to)	176-182
Number of pages	7
Journal	Kidney international
Volume	26
Issue number	2
DOIs	https://doi.org/10.1038/ki.1984.152
State	Published - 1984

Bibliographical note

Funding Information:
Acknowledgments This work was supported in part by United States Public Health Service grants Al 10704, HL 08570, and HL 17871, the Vikings Children's Fund, and grant RR 00400 from the General Research Cen-

Access

10.1038/ki.1984.152

OpenUrl availability

Full text

Cite this

@article{983a4e3a9c1341ffafb9db474b1bca83,

title = "Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E",

abstract = "A patient with idiopathic hypercalciuria and some features suggestive of Bartter syndrome is reported. Excessive urinary prostaglandin E (PGE) excretion and renal calcium leak were documented in this child. Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion. At the lowest levels of urinary PGE, the renal calcium leak was no longer evident although mild hypercalciuria persisted. These results suggest that PGE may play a role in some cases of idiopathic hypercalciuria.",

author = "M. Houser and B. Zimmerman and M. Davidman and C. Smith and A. Sinaiko and A. Fish",

note = "Funding Information: Acknowledgments This work was supported in part by United States Public Health Service grants Al 10704, HL 08570, and HL 17871, the Vikings Children's Fund, and grant RR 00400 from the General Research Cen-",

year = "1984",

doi = "10.1038/ki.1984.152",

language = "English (US)",

volume = "26",

pages = "176--182",

journal = "Kidney international",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E

AU - Houser, M.

AU - Zimmerman, B.

AU - Davidman, M.

AU - Smith, C.

AU - Sinaiko, A.

AU - Fish, A.

N1 - Funding Information: Acknowledgments This work was supported in part by United States Public Health Service grants Al 10704, HL 08570, and HL 17871, the Vikings Children's Fund, and grant RR 00400 from the General Research Cen-

PY - 1984

Y1 - 1984

N2 - A patient with idiopathic hypercalciuria and some features suggestive of Bartter syndrome is reported. Excessive urinary prostaglandin E (PGE) excretion and renal calcium leak were documented in this child. Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion. At the lowest levels of urinary PGE, the renal calcium leak was no longer evident although mild hypercalciuria persisted. These results suggest that PGE may play a role in some cases of idiopathic hypercalciuria.

AB - A patient with idiopathic hypercalciuria and some features suggestive of Bartter syndrome is reported. Excessive urinary prostaglandin E (PGE) excretion and renal calcium leak were documented in this child. Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion. At the lowest levels of urinary PGE, the renal calcium leak was no longer evident although mild hypercalciuria persisted. These results suggest that PGE may play a role in some cases of idiopathic hypercalciuria.

UR - http://www.scopus.com/inward/record.url?scp=0021152181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021152181&partnerID=8YFLogxK

U2 - 10.1038/ki.1984.152

DO - 10.1038/ki.1984.152

M3 - Article

C2 - 6389955

AN - SCOPUS:0021152181

SN - 0085-2538

VL - 26

SP - 176

EP - 182

JO - Kidney international

JF - Kidney international

IS - 2

ER -

Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this