Image-guided Application and Monitoring of Transcranial Focused Ultrasound in Realistic Human Head Phantom

P. D. O'Brien, Collin S. Smith, Emad S. Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dual-mode ultrasound arrays (DMUAs) have been used for monitoring and delivery of transcranial focused ultrasound (tFUS) in small-animal models in vivo. Synthetic-aperture (SA) imaging can be used for stereotaxic guidance, while high frame rate imaging modes, such as single-transmit focus (STF) imaging, can provide feedback for thermal and mechanical closed-loop control of lesion formation and neuromodulation. The objective of this study is to demonstrate the feasibility of DMUA guidance and control of tFUS application in a realistic human head phantom. A DMUA was used to image through the temporal bone of the phantom in SA and STF modes. Results from the SA imaging mode demonstrates the ability to image fine targets such as vessels with aneurysms. Additionally, subaperture processing of SA data shows it is possible to reduce reverberation. Results from the STF imaging mode show the feasibility of speckle tracking using transranial echo data, both with and without subaperture processing. These results demonstrate the value of judicial design of subaperture beamforming for identifying tissue structure and improving speckle statistics for high fidelity thermography and elastography. Results from tFUS-monitoring experiments will be given.

Original languageEnglish (US)
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages1898-1901
Number of pages4
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Externally publishedYes
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: Oct 6 2019Oct 9 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period10/6/1910/9/19

Bibliographical note

Funding Information:
Funded by NIH Grant NS 098781 from the National Institute of Health

Publisher Copyright:
© 2019 IEEE.

Keywords

  • Realistic Phantom
  • Subaperture beamforming
  • Transcranial FUS

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