Immune functions of cord blood cells before and after transplantation

Maria Grazia Roncarolo; Mike Bigler; Silvana Martino; Eliana Ciuti; Pier Angelo Tovo; John Wagner

doi:10.1089/scd.1.1996.5.157

Immune functions of cord blood cells before and after transplantation

Maria Grazia Roncarolo, Mike Bigler, Silvana Martino, Eliana Ciuti, Pier Angelo Tovo, John Wagner

Pediatrics - Blood/Marrow Transplant

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

There have been numerous reports of decreased acute and chronic graft-versus-host disease in patients receiving HLA-matched or HLA-disparate umbilical cord transplants. It has been proposed that this may be due to the unique properties of the neonatal immune system, which permit the development of tolerance to alloantigens. This review discusses experimental evidence contrasting the immune functions of cells derived from cord blood and those from peripheral blood.

Original language	English (US)
Pages (from-to)	157-160
Number of pages	4
Journal	Journal of Hematotherapy and Stem Cell Research
Volume	5
Issue number	2
DOIs	https://doi.org/10.1089/scd.1.1996.5.157
State	Published - Apr 1996

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abstract = "There have been numerous reports of decreased acute and chronic graft-versus-host disease in patients receiving HLA-matched or HLA-disparate umbilical cord transplants. It has been proposed that this may be due to the unique properties of the neonatal immune system, which permit the development of tolerance to alloantigens. This review discusses experimental evidence contrasting the immune functions of cells derived from cord blood and those from peripheral blood.",

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AU - Tovo, Pier Angelo

AU - Wagner, John

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Immune functions of cord blood cells before and after transplantation

Abstract

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