Abstract
BACKGROUND: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.\n\nMETHODS: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.\n\nRESULTS: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.\n\nCONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.
| Original language | English (US) |
|---|---|
| Volume | 24 |
| ISBN (Electronic) | 1538-7755 |
| State | Published - 2015 |
Keywords
- Adolescent
- Child
- Child, Preschool
- Diabetes Mellitus
- Diabetes Mellitus: etiology
- Down Syndrome
- Down Syndrome: complications
- Female
- Humans
- Immune System Diseases
- Immune System Diseases: etiology
- Immune System Diseases: immunology
- Infant
- Infant, Newborn
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid, Acute: etiology
- Leukemia, Myeloid, Acute: immunology
- Logistic Models
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Precursor Cell Lymphoblastic Leukemia-Lymphoma: et
- Precursor Cell Lymphoblastic Leukemia-Lymphoma: im
- Risk Factors
- Young Adult
