Immunofluorescence studies of renal basement membranes in dogs with spontaneous diabetes.

K. Jeraj, J. Basgen, R. M. Hardy, Carl A Osborne, A. F. Michael

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Renal tissue from 12 dogs with spontaneous diabetes and 16 control dogs were studied by light, immunofluorescence, and electron microscopies. Significant linear staining for immunoglobulin G and albumin were observed in the glomerular and tubular basement membranes of dogs with spontaneous diabetes--similar to that observed in human diabetes. On immunohistochemical grounds, it would appear that the dog with spontaneous diabetes is an appropriate model of diabetes in persons.

Original languageEnglish (US)
Pages (from-to)1162-1165
Number of pages4
JournalAmerican journal of veterinary research
Volume45
Issue number6
StatePublished - Jun 1 1984

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