Immunotherapy of a murine sarcoma using specific antitumor immune RNA

D. J.T. Webster; J. B. Cornacoff; D. A. Vallera; J. P. Dalmasso; M. C. Dodd; J. P. Minton

doi:10.1002/jso.2930120305

Immunotherapy of a murine sarcoma using specific antitumor immune RNA

D. J.T. Webster, J. B. Cornacoff, D. A. Vallera, J. P. Dalmasso, M. C. Dodd, J. P. Minton

Radiation Oncology

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Abstract

The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C₃H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

Original language	English (US)
Pages (from-to)	213-220
Number of pages	8
Journal	Journal of Surgical Oncology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/jso.2930120305
State	Published - 1979

Keywords

immune RNA
immunotherapy
murine sarcoma

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title = "Immunotherapy of a murine sarcoma using specific antitumor immune RNA",

abstract = "The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.",

keywords = "immune RNA, immunotherapy, murine sarcoma",

author = "Webster, {D. J.T.} and Cornacoff, {J. B.} and Vallera, {D. A.} and Dalmasso, {J. P.} and Dodd, {M. C.} and Minton, {J. P.}",

year = "1979",

doi = "10.1002/jso.2930120305",

language = "English (US)",

volume = "12",

pages = "213--220",

journal = "Journal of Surgical Oncology",

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T1 - Immunotherapy of a murine sarcoma using specific antitumor immune RNA

AU - Webster, D. J.T.

AU - Cornacoff, J. B.

AU - Vallera, D. A.

AU - Dalmasso, J. P.

AU - Dodd, M. C.

AU - Minton, J. P.

PY - 1979

Y1 - 1979

N2 - The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

AB - The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

KW - immune RNA

KW - immunotherapy

KW - murine sarcoma

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JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 3

ER -

Immunotherapy of a murine sarcoma using specific antitumor immune RNA

Abstract

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UN SDGs

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