Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients

Jennifer L. Reedy; Shahid Husain; Michael Ison; Timothy L. Pruett; Nina Singh; Joseph Heitman

doi:10.1128/AAC.50.4.1573-1577.2006

Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients

Jennifer L. Reedy, Shahid Husain, Michael Ison, Timothy L. Pruett, Nina Singh, Joseph Heitman

Surgery

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.

Original language	English (US)
Pages (from-to)	1573-1577
Number of pages	5
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	4
DOIs	https://doi.org/10.1128/AAC.50.4.1573-1577.2006
State	Published - Apr 2006

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Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. / Reedy, Jennifer L.; Husain, Shahid; Ison, Michael; Pruett, Timothy L.; Singh, Nina; Heitman, Joseph.

In: Antimicrobial agents and chemotherapy, Vol. 50, No. 4, 04.2006, p. 1573-1577.

Research output: Contribution to journal › Article › peer-review

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