TY - JOUR
T1 - Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients
AU - Reedy, Jennifer L.
AU - Husain, Shahid
AU - Ison, Michael
AU - Pruett, Timothy L.
AU - Singh, Nina
AU - Heitman, Joseph
PY - 2006/4
Y1 - 2006/4
N2 - In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.
AB - In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.
UR - http://www.scopus.com/inward/record.url?scp=33645796673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645796673&partnerID=8YFLogxK
U2 - 10.1128/AAC.50.4.1573-1577.2006
DO - 10.1128/AAC.50.4.1573-1577.2006
M3 - Article
C2 - 16569889
AN - SCOPUS:33645796673
VL - 50
SP - 1573
EP - 1577
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 4
ER -
