In vivo insulin secretion: Prostaglandin and adrenergic interrelationships

R. Paul Robertson

doi:10.1016/S0090-6980(74)80060-2

In vivo insulin secretion: Prostaglandin and adrenergic interrelationships

R. Paul Robertson

Research output: Contribution to journal › Article › peer-review

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Abstract

Infusion of prostaglandin (PG) E₁ in anesthetized dogs significantly lowered circulating insulin levels and inhibited insulin responses following intravenous glucose. A similar trend was observed with PGE₂. Alpha adrenergic blockade did not reverse the PGE₁ effect. Epinephrine infusion also inhibited glucose-stimulated insulin secretion, an effect that was not reversed by indomethacin. Therefore, in this investigative model, PGE₁ inhibited insulin secretion but no interdependency of PGE₁ and alpha adrenergic effects were found.

Original language	English (US)
Pages (from-to)	501-508
Number of pages	8
Journal	Prostaglandins
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/S0090-6980(74)80060-2
State	Published - Jun 25 1974
Externally published	Yes

Bibliographical note

Funding Information:
This work was presented in part at the Prostaglandin Conference at Stratton Mountain, Vermont, March 12, 1974, and was supported by the Veterans Administration Research and Education Program.

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title = "In vivo insulin secretion: Prostaglandin and adrenergic interrelationships",

abstract = "Infusion of prostaglandin (PG) E1 in anesthetized dogs significantly lowered circulating insulin levels and inhibited insulin responses following intravenous glucose. A similar trend was observed with PGE2. Alpha adrenergic blockade did not reverse the PGE1 effect. Epinephrine infusion also inhibited glucose-stimulated insulin secretion, an effect that was not reversed by indomethacin. Therefore, in this investigative model, PGE1 inhibited insulin secretion but no interdependency of PGE1 and alpha adrenergic effects were found.",

author = "Robertson, {R. Paul}",

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N2 - Infusion of prostaglandin (PG) E1 in anesthetized dogs significantly lowered circulating insulin levels and inhibited insulin responses following intravenous glucose. A similar trend was observed with PGE2. Alpha adrenergic blockade did not reverse the PGE1 effect. Epinephrine infusion also inhibited glucose-stimulated insulin secretion, an effect that was not reversed by indomethacin. Therefore, in this investigative model, PGE1 inhibited insulin secretion but no interdependency of PGE1 and alpha adrenergic effects were found.

AB - Infusion of prostaglandin (PG) E1 in anesthetized dogs significantly lowered circulating insulin levels and inhibited insulin responses following intravenous glucose. A similar trend was observed with PGE2. Alpha adrenergic blockade did not reverse the PGE1 effect. Epinephrine infusion also inhibited glucose-stimulated insulin secretion, an effect that was not reversed by indomethacin. Therefore, in this investigative model, PGE1 inhibited insulin secretion but no interdependency of PGE1 and alpha adrenergic effects were found.

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In vivo insulin secretion: Prostaglandin and adrenergic interrelationships

Abstract

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