TY - JOUR
T1 - In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI
AU - Branca, Rosa T.
AU - Zhang, Le
AU - Warren, Warren S.
AU - Auerbach, Edward
AU - Khanna, Arjun
AU - Degan, Simone
AU - Ugurbil, Kamil
AU - Maronpot, Robert
PY - 2013/9/10
Y1 - 2013/9/10
N2 - The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, and hypertension. However, clinical applications are currently limited by the lack of non-invasive tools for measuring mass and function of this tissue in humans. Here we present a new magnetic resonance imaging method based on the normally invisible intermolecular multiple-quantum coherence 1H MR signal. This method, which doesn't require special hardware modifications, can be used to overcome partial volume effect, the major limitation of MR-based approaches that are currently being investigated for the detection of BAT in humans. With this method we can exploit the characteristic cellular structure of BAT to selectively image it, even when (as in humans) it is intimately mixed with other tissues. We demonstrate and validate this method in mice using PET scans and histology. We compare this methodology with conventional 1H MR fat fraction methods. Finally, we investigate its feasibility for the detection of BAT in humans.
AB - The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, and hypertension. However, clinical applications are currently limited by the lack of non-invasive tools for measuring mass and function of this tissue in humans. Here we present a new magnetic resonance imaging method based on the normally invisible intermolecular multiple-quantum coherence 1H MR signal. This method, which doesn't require special hardware modifications, can be used to overcome partial volume effect, the major limitation of MR-based approaches that are currently being investigated for the detection of BAT in humans. With this method we can exploit the characteristic cellular structure of BAT to selectively image it, even when (as in humans) it is intimately mixed with other tissues. We demonstrate and validate this method in mice using PET scans and histology. We compare this methodology with conventional 1H MR fat fraction methods. Finally, we investigate its feasibility for the detection of BAT in humans.
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U2 - 10.1371/journal.pone.0074206
DO - 10.1371/journal.pone.0074206
M3 - Article
C2 - 24040203
AN - SCOPUS:84883829656
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 9
M1 - e74206
ER -
