In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children

Doris M. Ponce; Mary Eapen; Rodney Sparapani; Tracey A. O'Brien; Ka Wah Chan; Junfang Chen; John Craddock; Kirk R. Schultz; John E. Wagner; Miguel Angel Perales; Juliet N. Barker

doi:10.1016/j.bbmt.2015.08.022

In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children

Doris M. Ponce, Mary Eapen, Rodney Sparapani, Tracey A. O'Brien, Ka Wah Chan, Junfang Chen, John Craddock, Kirk R. Schultz, John E. Wagner, Miguel Angel Perales, Juliet N. Barker

Pediatrics - Blood/Marrow Transplant

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The inclusion of antithymocyte globulin (ATG) in cord blood transplantation is controversial. We evaluated outcomes according to ATG inclusion in 297 children and adolescents with acute lymphoblastic leukemia (ALL) who received myeloablative total body irradiation-based conditioning and either single-unit (74%) or double-unit (26%) grafts. Ninety-two patients (31%) received ATG and 205 (69%) did not. ATG recipients were more likely to be cytomegalovirus seronegative. The incidences of day 100 grades II to IV acute graft-versus-host disease (GVHD; 30% versus 54%, P = .0002) and chronic GVHD (22% versus 43%, P = .0008) were lower with ATG compared with non-ATG regimens. However, day 100 grades III to IV acute GVHD was comparable (11% versus 17%, P = .15). The 3-year incidences of transplant-related mortality (16% versus 17%, P = .98), relapse (17% versus 27%, P = .12), and leukemia-free survival (66% versus 55%, P = .23) in ATG and non-ATG recipients were similar. There were no differences in viral reactivation between treatment groups (60% versus 58%, P = .83). Therefore, the data suggest that incorporation of ATG with myeloablative conditioning regimens may be useful in reducing the risk of acute and chronic GVHD without any deleterious effect on transplant-related mortality, relapse, or leukemia-free survival in children and adolescents with ALL.

Original language	English (US)
Pages (from-to)	2173-2179
Number of pages	7
Journal	Biology of Blood and Marrow Transplantation
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/j.bbmt.2015.08.022
State	Published - Dec 2015

Bibliographical note

Funding Information:
Financial disclosure: The CIBMTR is supported by Public Health Service Grant /Cooperative Agreement U24-CA076518 from the National Cancer Institute (NCI) , the National Heart, Lung and Blood Institute (NHLBI) , and the National Institute of Allergy and Infectious Diseases ; Grant/Cooperative Agreement 5U10HL069294 from the NHLBI and NCI ; a contract ( HHSH250201200016C ) with Health Resources and Services Administration ; 2 grants ( N00014-13-1-0039 and N00014-14-1-0028 ) from the Office of Naval Research ; and grants from Actinium Pharmaceuticals ; Allos Therapeutics, Inc. ; Amgen, Inc. ; anonymous donation to the Medical College of Wisconsin; Ariad ; Be the Match Foundation ; Blue Cross and Blue Shield Association ; Celgene Corporation ; Chimerix, Inc. ; Fred Hutchinson Cancer Research Center ; Fresenius-Biotech North America, Inc. ; Gamida Cell Teva Joint Venture Ltd. ; Genentech, Inc. ; Gentium SpA ; Genzyme Corporation ; GlaxoSmithKline ; Health Research, Inc. Roswell Park Cancer Institute ; HistoGenetics, Inc. ; Incyte Corporation ; Jeff Gordon Children's Foundation ; Kiadis Pharma ; Medac GmbH ; The Medical College of Wisconsin ; Merck & Co, Inc. ; Millennium: The Takeda Oncology Co. ; Milliman USA, Inc. ; Miltenyi Biotec, Inc. ; National Marrow Donor Program ; Onyx Pharmaceuticals ; Optum Healthcare Solutions, Inc. ; Osiris Therapeutics, Inc. ; Otsuka America Pharmaceutical, Inc. ; Perkin Elmer, Inc. ; Remedy Informatics ; Sanofi US ; Seattle Genetics ; Sigma-Tau Pharmaceuticals ; Soligenix, Inc. ; St. Baldrick's Foundation ; StemCyte, A Global Cord Blood Therapeutics Co. ; Stemsoft Software, Inc. ; Swedish Orphan Biovitrum ; Tarix Pharmaceuticals ; TerumoBCT ; Teva Neuroscience, Inc. ; THERAKOS, Inc. ; University of Minnesota ; University of Utah ; and Wellpoint, Inc . The views expressed in this article do not reflect the official policy or position of the National Institutes of Health, the Department of the Navy, the Department of Defense, Health Resources and Services Administration, or any other agency of the US Government.

Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.

Keywords

Acute lymphoblastic leukemia
In vivo T cell depletion
Myeloablative conditioning

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Ponce, D. M., Eapen, M., Sparapani, R., O'Brien, T. A., Chan, K. W., Chen, J., Craddock, J., Schultz, K. R., Wagner, J. E., Perales, M. A., & Barker, J. N. (2015). In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children. Biology of Blood and Marrow Transplantation, 21(12), 2173-2179. https://doi.org/10.1016/j.bbmt.2015.08.022

Ponce, DM, Eapen, M, Sparapani, R, O'Brien, TA, Chan, KW, Chen, J, Craddock, J, Schultz, KR, Wagner, JE, Perales, MA & Barker, JN 2015, 'In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children', Biology of Blood and Marrow Transplantation, vol. 21, no. 12, pp. 2173-2179. https://doi.org/10.1016/j.bbmt.2015.08.022

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abstract = "The inclusion of antithymocyte globulin (ATG) in cord blood transplantation is controversial. We evaluated outcomes according to ATG inclusion in 297 children and adolescents with acute lymphoblastic leukemia (ALL) who received myeloablative total body irradiation-based conditioning and either single-unit (74%) or double-unit (26%) grafts. Ninety-two patients (31%) received ATG and 205 (69%) did not. ATG recipients were more likely to be cytomegalovirus seronegative. The incidences of day 100 grades II to IV acute graft-versus-host disease (GVHD; 30% versus 54%, P = .0002) and chronic GVHD (22% versus 43%, P = .0008) were lower with ATG compared with non-ATG regimens. However, day 100 grades III to IV acute GVHD was comparable (11% versus 17%, P = .15). The 3-year incidences of transplant-related mortality (16% versus 17%, P = .98), relapse (17% versus 27%, P = .12), and leukemia-free survival (66% versus 55%, P = .23) in ATG and non-ATG recipients were similar. There were no differences in viral reactivation between treatment groups (60% versus 58%, P = .83). Therefore, the data suggest that incorporation of ATG with myeloablative conditioning regimens may be useful in reducing the risk of acute and chronic GVHD without any deleterious effect on transplant-related mortality, relapse, or leukemia-free survival in children and adolescents with ALL.",

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In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children

Abstract

Bibliographical note

Keywords

UN SDGs

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