Instructing Memory in CD8+ Thymocytes

Katherine Maude Ashby; Kristin Ann Hogquist

doi:10.1016/j.it.2020.05.006

Instructing Memory in CD8⁺ Thymocytes

Katherine Maude Ashby, Kristin Ann Hogquist

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

Abstract

T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8⁺ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

Original language	English (US)
Pages (from-to)	556-558
Number of pages	3
Journal	Trends in Immunology
Volume	41
Issue number	7
DOIs	https://doi.org/10.1016/j.it.2020.05.006
State	Published - Jul 2020

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Publisher Copyright:
© 2020 Elsevier Ltd

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abstract = "T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such {\textquoteleft}memory phenotype{\textquoteright} (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.",

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