Insulin like growth factor 1 receptor signal transduction to the nucleus

S. A. Rosenzweig; B. S. Oemar; N. M. Law; U. T. Shankavaram; B. S. Miller

Insulin like growth factor 1 receptor signal transduction to the nucleus

S. A. Rosenzweig, B. S. Oemar, N. M. Law, U. T. Shankavaram, B. S. Miller

Pediatrics - Endocrine and Diabetes

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Abstract

The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.

Original language	English (US)
Pages (from-to)	159-168
Number of pages	10
Journal	Advances in Experimental Medicine and Biology
Volume	343
State	Published - Dec 1 1993

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AU - Miller, B. S.

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Insulin like growth factor 1 receptor signal transduction to the nucleus

Abstract

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