Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

Jonathan R. Brestoff; Craig B. Wilen; John R. Moley; Yongjia Li; Wei Zou; Nicole P. Malvin; Marina N. Rowen; Brian T. Saunders; Hongming Ma; Madison R. Mack; Barry L. Hykes; Dale R. Balce; Anthony Orvedahl; Jesse W. Williams; Nidhi Rohatgi; Xiaoyan Wang; Michael R. McAllaster; Scott A. Handley; Brian S. Kim; John G. Doench; Bernd H. Zinselmeyer; Michael S. Diamond; Herbert W. Virgin; Andrew E. Gelman; Steven L. Teitelbaum

doi:10.1016/j.cmet.2020.11.008

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

Jonathan R. Brestoff, Craig B. Wilen, John R. Moley, Yongjia Li, Wei Zou, Nicole P. Malvin, Marina N. Rowen, Brian T. Saunders, Hongming Ma, Madison R. Mack, Barry L. Hykes, Dale R. Balce, Anthony Orvedahl, Jesse W. Williams, Nidhi Rohatgi, Xiaoyan Wang, Michael R. McAllaster, Scott A. Handley, Brian S. Kim, John G. DoenchBernd H. Zinselmeyer, Michael S. Diamond, Herbert W. Virgin, Andrew E. Gelman, Steven L. Teitelbaum

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Abstract

Brestoff et al. show that adipose-tissue-resident macrophages acquire mitochondria from neighboring adipocytes in a heparan-sulfate-dependent process that is impaired in obesity. Genetic disruption of mitochondria uptake by macrophages reduces energy expenditure and exacerbates diet-induced obesity in mice, indicating that intercellular mitochondria transfer to macrophages mediates systemic metabolic homeostasis.

Original language	English (US)
Pages (from-to)	270-282.e8
Journal	Cell Metabolism
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2020.11.008
State	Published - Feb 2 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

beige adipose tissue
brown adipose tissue
horizontal mitochondria transfer
immunometabolism
intercellular mitochondria transfer
macrophage
metabolism
mitochondria
obesity
white adipose tissue

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Brestoff, J. R., Wilen, C. B., Moley, J. R., Li, Y., Zou, W., Malvin, N. P., Rowen, M. N., Saunders, B. T., Ma, H., Mack, M. R., Hykes, B. L., Balce, D. R., Orvedahl, A., Williams, J. W., Rohatgi, N., Wang, X., McAllaster, M. R., Handley, S. A., Kim, B. S., ... Teitelbaum, S. L. (2021). Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Cell Metabolism, 33(2), 270-282.e8. https://doi.org/10.1016/j.cmet.2020.11.008

Brestoff, JR, Wilen, CB, Moley, JR, Li, Y, Zou, W, Malvin, NP, Rowen, MN, Saunders, BT, Ma, H, Mack, MR, Hykes, BL, Balce, DR, Orvedahl, A, Williams, JW, Rohatgi, N, Wang, X, McAllaster, MR, Handley, SA, Kim, BS, Doench, JG, Zinselmeyer, BH, Diamond, MS, Virgin, HW, Gelman, AE & Teitelbaum, SL 2021, 'Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity', Cell Metabolism, vol. 33, no. 2, pp. 270-282.e8. https://doi.org/10.1016/j.cmet.2020.11.008

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abstract = "Brestoff et al. show that adipose-tissue-resident macrophages acquire mitochondria from neighboring adipocytes in a heparan-sulfate-dependent process that is impaired in obesity. Genetic disruption of mitochondria uptake by macrophages reduces energy expenditure and exacerbates diet-induced obesity in mice, indicating that intercellular mitochondria transfer to macrophages mediates systemic metabolic homeostasis.",

keywords = "beige adipose tissue, brown adipose tissue, horizontal mitochondria transfer, immunometabolism, intercellular mitochondria transfer, macrophage, metabolism, mitochondria, obesity, white adipose tissue",

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doi = "10.1016/j.cmet.2020.11.008",

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KW - intercellular mitochondria transfer

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KW - mitochondria

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Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

Abstract

Bibliographical note

Keywords

UN SDGs

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