Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging

Matthew J. Linman, Abdennour Abbas, Quan Cheng

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Ever since the advent of surface plasmon resonance (SPR) and SPR imaging (SPRi) in the early 1990s, their use in biomolecular interaction analysis (BIA) has expanded phenomenally. An important research area in SPR sensor development is the design of novel and effective interfaces that allow for the probing of a variety of chemical and biological interactions in a highly selective and sensitive manner. A well-designed and robust interface is a necessity to obtain both accurate and pertinent biological information. This review covers the recent research efforts in this area with a specific focus towards biointerfaces, new materials for SPR biosensing, and novel array designs for SPR imaging. Perspectives on the challenges ahead and next steps for SPR technology are discussed.

Original languageEnglish (US)
Pages (from-to)2759-2767
Number of pages9
JournalAnalyst
Volume135
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint Dive into the research topics of 'Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging'. Together they form a unique fingerprint.

Cite this