TY - JOUR
T1 - Interhemispheric Asymmetry in Distribution of Infarct Lesions among Acute Ischemic Stroke Patients Presenting to Hospital
AU - Payabvash, Seyedmehdi
AU - Taleb, Shayandokht
AU - Benson, John C.
AU - McKinney, Alexander M.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Backgrounds This study aimed to investigate the possible asymmetric distribution of acute ischemic infarct lesions between patients with right-sided stroke versus left-sided stroke. Methods Acute ischemic stroke patients with unilateral infarct who underwent magnetic resonance imaging scan within 24 hours of onset were included. Infarct lesions were segmented on diffusion-weighted-imaging series and coregistered on the MNI-152 brain map. After flipping all lesions to the left side, voxel-based analysis was performed to evaluate for asymmetric distribution of infarct lesions using the stroke side as an independent variable. Symptom severity at admission was evaluated using the National Institutes of Health Stroke Scale score, and early clinical outcome with the modified Rankin Scale score at discharge. Results Of the 218 patients included in this study, 110 had right-sided ischemic infarcts whereas 108 had left-sided ischemic infarcts. There was no significant difference between patients with right-sided stroke versus left-sided stroke in terms of admission symptom severity, rate of treatment, stroke risk factors, and early clinical outcome. However, voxel-based analysis showed that ischemic infarcts of insular ribbon and lentiform nucleus were asymmetrically more common on the left-sided stroke compared to the right-sided stroke. The admission symptoms were more severe among patients with left insular ribbon and lentiform nucleus infarct compared to those with infarction of mirrored right anatomical regions (P = .019). Conclusions Acute ischemic infarcts of the left insular ribbon and lentiform nucleus are asymmetrically more common compared to mirrored counterpart regions, presumably due to more severe symptoms at presentation. Otherwise, distribution of symptomatic infarcts to the rest of the brain is roughly symmetric.
AB - Backgrounds This study aimed to investigate the possible asymmetric distribution of acute ischemic infarct lesions between patients with right-sided stroke versus left-sided stroke. Methods Acute ischemic stroke patients with unilateral infarct who underwent magnetic resonance imaging scan within 24 hours of onset were included. Infarct lesions were segmented on diffusion-weighted-imaging series and coregistered on the MNI-152 brain map. After flipping all lesions to the left side, voxel-based analysis was performed to evaluate for asymmetric distribution of infarct lesions using the stroke side as an independent variable. Symptom severity at admission was evaluated using the National Institutes of Health Stroke Scale score, and early clinical outcome with the modified Rankin Scale score at discharge. Results Of the 218 patients included in this study, 110 had right-sided ischemic infarcts whereas 108 had left-sided ischemic infarcts. There was no significant difference between patients with right-sided stroke versus left-sided stroke in terms of admission symptom severity, rate of treatment, stroke risk factors, and early clinical outcome. However, voxel-based analysis showed that ischemic infarcts of insular ribbon and lentiform nucleus were asymmetrically more common on the left-sided stroke compared to the right-sided stroke. The admission symptoms were more severe among patients with left insular ribbon and lentiform nucleus infarct compared to those with infarction of mirrored right anatomical regions (P = .019). Conclusions Acute ischemic infarcts of the left insular ribbon and lentiform nucleus are asymmetrically more common compared to mirrored counterpart regions, presumably due to more severe symptoms at presentation. Otherwise, distribution of symptomatic infarcts to the rest of the brain is roughly symmetric.
KW - Ischemic infarct
KW - hemisphere
KW - laterality
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84978536054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978536054&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2016.06.019
DO - 10.1016/j.jstrokecerebrovasdis.2016.06.019
M3 - Article
C2 - 27373730
AN - SCOPUS:84978536054
SN - 1052-3057
VL - 25
SP - 2464
EP - 2469
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 10
ER -