Abstract
Background: Periapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a “metabolically-triggered” low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. The host immune system is therefore considered the common fundamental mechanism of both disease conditions. Method: We have reviewed >200 articles to discuss the interrelationship between periapical lesions and metabolic disorders including type 2 diabetes mellitus, hypertension, and non-alcoholic fatty liver diseases (NAFLD), and their common pathological background in immunology/osteoimmunology and cytokine biology. Results: An elevated inflammatory state caused by metabolic disorders can impact the clinical outcome of periapical lesions and interfere with wound healing after endodontic treatment. Although additional well-designed clinical studies are needed, periapical lesions appear to affect insulin sensitivity and exacerbate non-alcoholic steatohepatitis. Conclusion: Immune regulatory cytokines produced by various cell types, including immune cells and adipose tissue, play an important role in this interrelationship.
Original language | English (US) |
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Pages (from-to) | 2204-2215 |
Number of pages | 12 |
Journal | Current pharmaceutical design |
Volume | 22 |
Issue number | 15 |
DOIs | |
State | Published - Apr 1 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Bentham Science Publishers.
Keywords
- Cytokines
- Hypertension
- Immunity
- Inflammation
- Metabolic disorders
- NAFLD
- Periapical lesion
- Type 2 diabetes