Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

Emily A. Thompson, Jason S. Mitchell, Lalit K. Beura, David J. Torres, Paulus Mrass, Mark J. Pierson, Judy L. Cannon, David Masopust, Brian T. Fife, Vaiva Vezys

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Using in vivo imaging of pathogen- and self-specific CD8 T cells in the small intestine, Thompson et al. reveal dynamic changes in the speed and volume of tissue surveyed by CD8 T cells over time after antigen encounter. Migration was CD103 independent, and motility was most limited during the memory response.

Original languageEnglish (US)
Pages (from-to)2859-2867.e4
JournalCell reports
Volume26
Issue number11
DOIs
StatePublished - Mar 12 2019

Bibliographical note

Funding Information:
We would like to thank Dr. J. Michael Stolley for schematic artistry; Dr. Mark J. Miller for help with SI TPLSM development; Drs. Yoji Shimizu and Brandon Burbach for providing OT-I-GFP mice; and Drs. Stephen Jameson, Kris Hogquist, and Tessa Bergsbaken for sharing Kaede transgenic mice and Yptb-OVA. This work was funded by a University of Minnesota Academic Health Center Seed Grant (to V.V.), NIH grant T32AI007313 (to E.A.T.), and by the University of Minnesota Doctoral Dissertation Fellowship (to E.A.T.). B.T.F. and J.S.M. are supported by NIH R01 AI106791 and P01 AI35296. D.J.T. is supported by NIH UTEP BUILDing SCHOLARS award RL5GM118969 and an NIH Institutional Development Award (IDeA) P20GM1034. D.M. is supported by NIH R01 AI084913.

Funding Information:
We would like to thank Dr. J. Michael Stolley for schematic artistry; Dr. Mark J. Miller for help with SI TPLSM development; Drs. Yoji Shimizu and Brandon Burbach for providing OT-I-GFP mice; and Drs. Stephen Jameson, Kris Hogquist, and Tessa Bergsbaken for sharing Kaede transgenic mice and Yptb-OVA. This work was funded by a University of Minnesota Academic Health Center Seed Grant (to V.V.), NIH grant T32AI007313 (to E.A.T.), and by the University of Minnesota Doctoral Dissertation Fellowship (to E.A.T.). B.T.F. and J.S.M. are supported by NIH R01 AI106791 and P01 AI35296 . D.J.T. is supported by NIH UTEP BUILDing SCHOLARS award RL5GM118969 and an NIH Institutional Development Award (IDeA) P20GM1034 . D.M. is supported by NIH R01 AI084913 .

Publisher Copyright:
© 2019 The Author(s)

Keywords

  • 2-photon microscopy
  • CD8 T cells
  • T cell migration
  • immune surveillance
  • integrins
  • mathematical modeling
  • motility
  • mucosal immunity
  • resident memory T cells
  • tolerance

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