Abstract
Using in vivo imaging of pathogen- and self-specific CD8 T cells in the small intestine, Thompson et al. reveal dynamic changes in the speed and volume of tissue surveyed by CD8 T cells over time after antigen encounter. Migration was CD103 independent, and motility was most limited during the memory response.
Original language | English (US) |
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Pages (from-to) | 2859-2867.e4 |
Journal | Cell reports |
Volume | 26 |
Issue number | 11 |
DOIs | |
State | Published - Mar 12 2019 |
Bibliographical note
Publisher Copyright:© 2019 The Author(s)
Keywords
- 2-photon microscopy
- CD8 T cells
- T cell migration
- immune surveillance
- integrins
- mathematical modeling
- motility
- mucosal immunity
- resident memory T cells
- tolerance