Inversion of DNA charge by a positive polymer via fractionalization of the polymer charge

T. T. Nguyen, B. I. Shklovskii

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Charge inversion of a DNA double helix by an oppositely charged flexible polyelectrolyte (PE) is widely used for gene delivery. It is considered here in terms of discrete charges of DNA. We concentrate on the worst scenario case when in the neutral state of the DNA-PE complex, each of the DNA charges is locally compensated by a PE charge and show that charge inversion exists even in this case. When an additional PE molecule is adsorbed by DNA, its charge gets fractionalized into monomer charges of defects (tails and arches) on the background of the perfectly neutralized DNA. These charges spread all over the DNA eliminating the self-energy of PE. Fractionalization leads to a substantial charge inversion of DNA.

Original languageEnglish (US)
Title of host publicationJournal De Physique. IV : JP
EditorsS. Brazovskii, N. Kirova, P. Monceau
Volume12
Edition9
StatePublished - Nov 2002
EventInternational Workshop on Electronic Crystals - ECRYS 2002 - Saint Flour, France
Duration: Sep 2 2002Sep 7 2002

Other

OtherInternational Workshop on Electronic Crystals - ECRYS 2002
CountryFrance
CitySaint Flour
Period9/2/029/7/02

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