Isolated tramadol overdose associated with brugada ECG pattern

Jon B. Cole; Srinivasan Sattiraju; Elisabeth F. Bilden; Richard W. Asinger; Stefan C. Bertog

doi:10.1111/j.1540-8159.2010.02924.x

Isolated tramadol overdose associated with brugada ECG pattern

Jon B. Cole, Srinivasan Sattiraju, Elisabeth F. Bilden, Richard W. Asinger, Stefan C. Bertog

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)

Original language	English (US)
Pages (from-to)	e219-e221
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	35
Issue number	8
DOIs	https://doi.org/10.1111/j.1540-8159.2010.02924.x
State	Published - Aug 2012
Externally published	Yes

Keywords

ECG pattern
brugada
sodium channel blockers
tramadol

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title = "Isolated tramadol overdose associated with brugada ECG pattern",

abstract = "Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)",

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AU - Sattiraju, Srinivasan

AU - Bilden, Elisabeth F.

AU - Asinger, Richard W.

AU - Bertog, Stefan C.

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N2 - Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)

AB - Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221)

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Isolated tramadol overdose associated with brugada ECG pattern

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