Kidney transplant half-life (t [1/2]) after rapid discontinuation of prednisone

Arthur J. Matas, Kristen Gillingham, Raja Kandaswamy, Ty B. Dunn, William D. Payne, David E.R. Sutherland, Abhinav Humar

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Protocols incorporating rapid discontinuation of prednisone (RDP) after kidney transplantation have been associated with good short-term results. However, concern remains that RDP will be associated with decreased long-term graft survival rates. We compared kidney transplant half-life (t1/2) for recipients treated with antibody induction, calcineurin inhibitor, antimetabolite, and RDP versus historical controls treated with antibody induction, calcineurin inhibitor, antimetabolite, and maintenance prednisone. For both living and deceased donor recipients, we found no difference between groups. We also found no differences in rate of graft loss to acute rejection or to tubular atrophy and interstitial fibrosis. Our study suggests that long-term graft outcome is not decreased when using RDP protocols versus chronic maintenance prednisone.

Original languageEnglish (US)
Pages (from-to)100-102
Number of pages3
JournalTransplantation
Volume87
Issue number1
DOIs
StatePublished - Jan 15 2009

Keywords

  • Immunosuppression
  • Kidney transplantation
  • Prednisone

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