Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

Research output: Contribution to journalShort surveypeer-review

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Abstract

Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalTrends in Cell Biology
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2008

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