Lack of a relationship between plasma fibroblast growth factor-23 and phosphate utilization in young chicks

Maria Horvat-Gordon, Jill A. Hadley, Kahina Ghanem, Roland M. Leach

Research output: Contribution to journalArticlepeer-review

Abstract

Fibroblast growth factor 23 (FGF-23) is proposed to be the hormone that controls phosphate (P) homeostasis in chickens. This study was initiated to investigate the effect of feeding young chicks diets that were either adequate (0.45%) or marginal (0.25%) in available P content on plasma FGF-23 levels. The dietary level of available P significantly (P ≤ 0.05) affected bone mineralization and bone length, but was without effect (P > 0.05) on growth rate and circulating FGF-23 concentrations. Substantial individual variation in bone mineralization and plasma FGF-23 levels was observed, and the correlation between these two variables was non-significant (P > 0.05). This suggested that there was no alteration in FGF-23 activity in response to suboptimal dietary P intake. The relationship of these observations to studies on the immunosuppression of FGF-23 activity is subsequently discussed.

Original languageEnglish (US)
Pages (from-to)1762-1765
Number of pages4
JournalPoultry science
Volume98
Issue number4
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Available phosphorus
  • Bone mineralization
  • Chicken
  • FGF-23
  • Phosphate utilization

PubMed: MeSH publication types

  • Journal Article

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