Large improvement of RF transmission efficiency and reception sensitivity for human in vivo 31P MRS imaging using ultrahigh dielectric constant materials at 7 T

Byeong Yeul Lee, Xiao Hong Zhu, Sebastian Rupprecht, Michael T. Lanagan, Qing X. Yang, Wei Chen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In vivo 31P MRS provides a unique and important imaging tool for studying high-energy phosphate metabolism and bioenergetics noninvasively. However, compared to 1H MRS, 31P MRS with a relatively low gyromagnetic ratio (γ) has a lower and limited sensitivity even at ultrahigh field. The proof of concept has been recently demonstrated that the use of high dielectric constant (HDC) materials between RF coil and object sample could increase MRI signal and reduce required RF transmission power for reaching the same RF pulse flip angle in the region of interest. For low-γ MRS applications operated at relatively lower frequency, however, it demands the dielectric materials with a much higher permittivity for achieving optimal performance. We conducted a 31P MRS imaging study using ultra-HDC (uHDC; with a relative permittivity of ~ 1200) material blocks incorporated with an RF volume coil at ultrahigh field of 7.0 T. The experimental results from phantom and human calf muscle demonstrate that the uHDC technique significantly enhanced RF magnetic transmit field (B1+) and reception field (B1) and the gain could reach up to two folds in the tissue near the uHDC blocks. The overall results indicate that the incorporation of the uHDC materials having an appropriate permittivity value with a RF coil can significantly increase detection sensitivity and reduces RF transmission power for X-nuclei MRS applications at ultrahigh field. The uHDC technology could provide an efficient, cost-effective engineering solution for achieving high detection sensitivity and concurrently minimizing tissue heating concern for human MRS and MRI applications.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalMagnetic Resonance Imaging
StatePublished - Oct 2017

Bibliographical note

Funding Information:
This work was partly supported by NIH Grants R24 MH106049 and R24 MH106049 S1, RO1 NS057560, NS070839 and MH111413, S10 RR026783, P41 EB015894, P30 NS076408; a grant from Penn State Hershey Neuroscience Institute, and the AHC Faculty Research Development (FRD) grant from the University of Minnesota. The authors thank Drs. Kamil Ugurbil and Gregor Adriany for technical support and scientific discussion.

Publisher Copyright:
© 2017


  • B magnetic field
  • Detection sensitivity.
  • P MRS
  • RF reception
  • RF transmission
  • Ultrahigh dielectric constant material


Dive into the research topics of 'Large improvement of RF transmission efficiency and reception sensitivity for human in vivo <sup>31</sup>P MRS imaging using ultrahigh dielectric constant materials at 7 T'. Together they form a unique fingerprint.

Cite this