Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

M. C. Carroll; P. Katzman; E. M. Alicot; B. H. Koller; D. E. Geraghty; H. T. Orr; J. L. Strominger; T. Spies

doi:10.1073/pnas.84.23.8535

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

M. C. Carroll, P. Katzman, E. M. Alicot, B. H. Koller, D. E. Geraghty, H. T. Orr, J. L. Strominger, T. Spies

Laboratory Medicine and Pathology

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Abstract

The tumor necrosis factor (TNF) α and β gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

Original language	English (US)
Pages (from-to)	8535-8539
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	84
Issue number	23
DOIs	https://doi.org/10.1073/pnas.84.23.8535
State	Published - 1987

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title = "Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes",

abstract = "The tumor necrosis factor (TNF) α and β gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.",

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year = "1987",

doi = "10.1073/pnas.84.23.8535",

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AU - Carroll, M. C.

AU - Katzman, P.

AU - Alicot, E. M.

AU - Koller, B. H.

AU - Geraghty, D. E.

AU - Orr, H. T.

AU - Strominger, J. L.

AU - Spies, T.

PY - 1987

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AB - The tumor necrosis factor (TNF) α and β gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

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Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

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