Linkage of an Alzheimer disease susceptibility locus to markers on human chromosome 21

L. L. Heston, H. T. Orr, S. S. Rich, J. A. White

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We assessed linkage between Alzheimer disease (AD) and restriction fragment length polymorphisms (RFLPs) from human chromosome 21 in 8 families selected because of multiple occurrences of AD and large size. Sib-pair analysis demonstrated significant evidence for linkage between 2 markers (D21S1 and D21S11) and disease. Two markers, D21S13 and D21S52, did not yield evidence in favor of linkage to disease and a 5th, D21S16, was uninformative. The results confirm that a susceptibility locus for Alzheimer disease is located on chromosome 21. In contrast to other investigators who demonstrated linkage between AD and chromosome 21 loci, we found evidence in favor of linkage in both late- (greater than age 65) and early-onset families.

Original languageEnglish (US)
Pages (from-to)449-453
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume40
Issue number4
DOIs
StatePublished - Jan 1 1991

Keywords

  • Alzheimer disease
  • chromosome 21 linkage
  • chromosome 21 markers
  • genetic mapping
  • sib-pair analysis

Fingerprint Dive into the research topics of 'Linkage of an Alzheimer disease susceptibility locus to markers on human chromosome 21'. Together they form a unique fingerprint.

Cite this