TY - JOUR
T1 - Longevity candidate genes and their association with personality traits in the elderly
AU - Luciano, Michelle
AU - Lopez, Lorna M.
AU - De Moor, Marleen H M
AU - Harris, Sarah E.
AU - Davies, Gail
AU - Nutile, Teresa
AU - Krueger, Robert F.
AU - Esko, Tõnu
AU - Schlessinger, David
AU - Toshiko, Tanaka
AU - Derringer, Jaime L.
AU - Realo, Anu
AU - Hansell, Narelle K.
AU - Pergadia, Michele L.
AU - Pesonen, Anu Katriina
AU - Sanna, Serena
AU - Terracciano, Antonio
AU - Madden, Pamela A F
AU - Penninx, Brenda
AU - Spinhoven, Philip
AU - Hartman, Catherina A.
AU - Oostra, Ben A.
AU - Janssens, A. Cecile J W
AU - Eriksson, Johan G.
AU - Starr, John M.
AU - Cannas, Alessandra
AU - Ferrucci, Luigi
AU - Metspalu, Andres
AU - Wright, Margeret J.
AU - Heath, Andrew C.
AU - van Duijn, Cornelia M.
AU - Bierut, Laura J.
AU - Raikkonen, Katri
AU - Martin, Nicholas G.
AU - Ciullo, Marina
AU - Rujescu, Dan
AU - Boomsma, Dorret I.
AU - Deary, Ian J.
PY - 2012/3
Y1 - 2012/3
N2 - Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P<0.0002), but there was an over-representation of nominally significant (P<0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
AB - Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P<0.0002), but there was an over-representation of nominally significant (P<0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
KW - Aging
KW - Anxiety
KW - Depressive symptoms
KW - Genetics
KW - IPIP personality
KW - NEO personality
UR - http://www.scopus.com/inward/record.url?scp=84855838135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855838135&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.32013
DO - 10.1002/ajmg.b.32013
M3 - Article
C2 - 22213687
AN - SCOPUS:84855838135
SN - 1552-4841
VL - 159 B
SP - 192
EP - 200
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 2
ER -