Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women

K. Brock, W. Y. Huang, D. R. Fraser, L. Ke, M. Tseng, R. Stolzenberg-Solomon, U. Peters, J. Ahn, M. Purdue, R. S. Mason, C. McCarty, R. G. Ziegler, B. Graubard

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

The aim of this study was to investigate modifiable predictors of vitamin D status in healthy individuals, aged 55-74, and living across the USA. Vitamin D status [serum 25-hydroxyvitamin D (25(OH)D)] was measured along with age and season at blood collection, demographics, anthropometry, physical activity (PA), diet, and other lifestyle factors in 1357 male and 1264 female controls selected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Multivariate linear and logistic regression analyses were used to identify associations with vitamin D status. Three%, 29% and 79% of the population had serum 25(OH)D levels <25, <50 and <80nmol/L, respectively. The major modifiable predictors of low vitamin D status were low vitamin D dietary and supplement intake, body mass index (BMI) >30kg/m2, physical inactivity (PA) and low milk and calcium supplement intake. In men, 25(OH)D was determined more by milk intake on cereal and in women, by vitamin D and calcium supplement and menopausal hormone therapy (MHT) use. Thus targeting an increase in vigorous activity and vitamin D and calcium intake and decreasing obesity could be public health interventions independent of sun exposure to improve vitamin D status in middle-aged Americans.

Original languageEnglish (US)
Pages (from-to)462-466
Number of pages5
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume121
Issue number1-2
DOIs
StatePublished - Jul 2010

Keywords

  • 25(OH)D
  • Body mass index (BMI)
  • Calcium supplement intake
  • Exercise
  • Menopausal hormone therapy (MHT)
  • Milk intake
  • Obesity
  • Physical activity
  • Vitamin D deficiency
  • Vitamin D dietary and supplement intake
  • Vitamin D status

Fingerprint

Dive into the research topics of 'Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women'. Together they form a unique fingerprint.

Cite this