Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins

P. C. Doherty, S. Hou, P. J. Southern

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48 Scopus citations

Abstract

Lymphocytic choriomeningitis virus (LCMV) induces a chronic, wasting syndrome when injected intracerebrally into H-2b mice homozygous for a β2-microglobulin (β2-m (-/-)) gene disruption. These mice have very few CD8+ T cells and express little class I MHC glycoprotein, though minimal levels of the H-2Db molecule have been detected on in vitro cultured β2-m (-/-) cells. The inderlying immunopathological process in these β2-m (-/-) mice is mediated by virus immune CD4+ effectors. However, adoptively transferred CD8+ T cells from normal, LCMV-infected H-2Db compatible donors induce significant (but low level) meningitis in β2-m (-/-) recipients. Such mice develop neither the neurological disease characteristic of LCM nor the persistent, though generally non-fatal, debility that occurs when only the CD4+ T cell subset is involved.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalJournal of Neuroimmunology
Volume46
Issue number1-2
DOIs
StatePublished - Jul 1993

Keywords

  • Debility caused by CD4 T cells
  • Immunopathology
  • Meningitis
  • T cell specificity
  • T cell targeting

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