The heating performance of magnetic nanoparticles (MNPs) under an alternating magnetic field (AMF) is dependent on several factors. Optimizing these factors improves the heating efficiency for cancer therapy and meanwhile lowers the MNP treatment dosage. AMF is one of the most easily controllable variables to enhance the efficiency of heat generation. This paper investigated the optimal magnetic field strength and frequency for an assembly of magnetite nanoparticles. For hyperthermia treatment in clinical applications, monodispersed NPs are forming nanoclusters in target regions where a strong magnetically interactive environment is anticipated, which leads to a completely different situation than MNPs in ferrofluids. Herein, the energy barrier model is revisited and Néel relaxation time is tailored for high MNP packing densities. AMF strength and frequency are customized for different magnetite NPs to achieve the highest power generation and the best hyperthermia performance.
Bibliographical noteFunding Information:
The authors thank the support from the Institute of Engineering in Medicine, National Science Foundation MRSEC facility program, the Distinguished McKnight University Professorship, UROP program, MNDrive STEM program, MNDrive program, and the Interdisciplinary Doctoral Fellowship from the University of Minnesota. Authors thank the fruitful discussion with Yipeng Jiao from Department of Electrical Engineering, University of Minnesota.
© 2017 Author(s).