Abstract
In recent years, magnetic particle spectroscopy (MPS) has emerged as a new technology for immunoassay applications. In MPS, alternating magnetic fields are applied to magnetic nanoparticles (MNPs). The magnetic responses of these nanoparticles are collected and recorded by a pair of specially designed pick-up coils. These magnetic responses contain higher harmonics that are specific to the physical changes of the nanoparticles such as the binding events of target analytes to nanoparticles. This volumetric-based bioassay method analyses the response signal from the whole nanoparticle suspension, thus, allows one step and wash-free immunoassay with minimum technical requirements. In this work, we developed a handheld MPS system as a future highly sensitive, cheap, in vitro, and easy-to-use point-of-care (POC) detection kit.
Original language | English (US) |
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Title of host publication | Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020 |
Publisher | American Society of Mechanical Engineers (ASME) |
ISBN (Electronic) | 9780791883549 |
DOIs | |
State | Published - 2020 |
Event | 2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States Duration: Apr 6 2020 → Apr 9 2020 |
Publication series
Name | Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020 |
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Conference
Conference | 2020 Design of Medical Devices Conference, DMD 2020 |
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Country/Territory | United States |
City | Minneapolis |
Period | 4/6/20 → 4/9/20 |
Bibliographical note
Publisher Copyright:Copyright © 2020 ASME
Keywords
- Handheld device
- Harmonics
- Magnetic nanoparticle
- Magnetic particle spectroscopy