Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo

D. Sostman; S. Rockwell; G. J.W. Smith; J. C. Gore; K. A. Kennedy; A. Habib; J. J. Fischer; I. M. Armitage; W. Holcomb

doi:10.1097/00004424-198804000-00007

Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo

D. Sostman, S. Rockwell, G. J.W. Smith, J. C. Gore, K. A. Kennedy, A. Habib, J. J. Fischer, I. M. Armitage, W. Holcomb

Biochemistry, Molecular Biology, and Biophysics (TMED)

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Abstract

We studied histology, findings on H-l magnetic resonance (MR) imaging, and correlations of P-31 MR spectroscopy with microe-lectrode pH and pO₂ measurements in the BA1112 rhabdomy-osarcoma in WAG/Rij/Y rats. Intratumoral hemorrhage was a prominent feature on MR images and pathologic specimens. Eosinophilic necrosis could be seen microscopically but was not discernible on images. The peaks seen on P-31 MR spectra were similar to those reported in other tumors. The intratumoral pH was neutral despite low pO₂ values and P-31 MR evidence for unpaired metabolic status.

Original language	English (US)
Pages (from-to)	277-288
Number of pages	12
Journal	Investigative Radiology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1097/00004424-198804000-00007
State	Published - Apr 1988

Keywords

Magnetic resonance imaging
Magnetic resonance spectroscopy
Neoplasm histology
Neoplasm physiology

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AU - Rockwell, S.

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AU - Gore, J. C.

AU - Kennedy, K. A.

AU - Habib, A.

AU - Fischer, J. J.

AU - Armitage, I. M.

AU - Holcomb, W.

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AB - We studied histology, findings on H-l magnetic resonance (MR) imaging, and correlations of P-31 MR spectroscopy with microe-lectrode pH and pO2 measurements in the BA1112 rhabdomy-osarcoma in WAG/Rij/Y rats. Intratumoral hemorrhage was a prominent feature on MR images and pathologic specimens. Eosinophilic necrosis could be seen microscopically but was not discernible on images. The peaks seen on P-31 MR spectra were similar to those reported in other tumors. The intratumoral pH was neutral despite low pO2 values and P-31 MR evidence for unpaired metabolic status.

KW - Magnetic resonance imaging

KW - Magnetic resonance spectroscopy

KW - Neoplasm histology

KW - Neoplasm physiology

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Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo

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