Major histocompatibility complex i of swine respiratory cells presents conserved regions of influenza proteins

Elise A Lamont, Erin Poulin, Srinand Sreevatsan, Maxim C Cheeran

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Influenza A virus in swine (IAV-S) is a prevalent respiratory pathogen in pigs that has deleterious consequences to animal and human health. Pigs represent an important reservoir for influenza and potential mixing vessel for novel gene reassortments. Despite the central role of pigs in recent influenza outbreaks, much remains unknown about the impact of swine immunity on IAV-S transmission, pathogenesis, and evolution. An incomplete understanding of interactions between the porcine immune system and IAV-S has hindered development of new diagnostic tools and vaccines. In order to address this gap in knowledge, we identified swine leukocyte antigen (SLA) restricted IAV-S peptides presented by porcine airway epithelial cells using an immunoproteomics approach. The majority of MHC-associated peptides belonged to matrix 1, nucleoprotein and nonstructural 1 proteins. Future investigation of the potential cross-reactive nature of these peptides is needed to confirm antigen recognition by cytotoxic T lymphocytes and their utility as vaccine candidates.

Original languageEnglish (US)
Article number001008
Pages (from-to)303-308
Number of pages6
JournalJournal of General Virology
Volume99
Issue number3
DOIs
StatePublished - Mar 2018

Bibliographical note

Funding Information:
This project was supported in part by the College of Veterinary Medicine Emerging Zoonotic Diseases Signature Program, USDA-NIFA SAES funds (Project number MIN 62-050).

Keywords

  • Epitopes
  • Influenza
  • Major histocompatibility complex
  • Matrix protein
  • Nucleoprotein
  • Pig
  • Swine influenza virus
  • T cells

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