Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study

Jessica R B Musselman; Michael K. Georgieff; Julie A. Ross; Gail E. Tomlinson; James Feusner; Mark Krailo; Logan G. Spector

doi:10.1016/j.canep.2012.12.005

Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study

Jessica R B Musselman, Michael K. Georgieff, Julie A. Ross, Gail E. Tomlinson, James Feusner, Mark Krailo, Logan G. Spector

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.

Original language	English (US)
Pages (from-to)	318-320
Number of pages	3
Journal	Cancer Epidemiology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.canep.2012.12.005
State	Published - Jun 2013

Keywords

Body weight changes
Case-control studies
Hepatoblastoma
Pregnancy complications
Self medication

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study",

abstract = "Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.",

keywords = "Body weight changes, Case-control studies, Hepatoblastoma, Pregnancy complications, Self medication",

author = "Musselman, {Jessica R B} and Georgieff, {Michael K.} and Ross, {Julie A.} and Tomlinson, {Gail E.} and James Feusner and Mark Krailo and Spector, {Logan G.}",

year = "2013",

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doi = "10.1016/j.canep.2012.12.005",

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T2 - A Children's Oncology Group (COG) study

AU - Musselman, Jessica R B

AU - Georgieff, Michael K.

AU - Ross, Julie A.

AU - Tomlinson, Gail E.

AU - Feusner, James

AU - Krailo, Mark

AU - Spector, Logan G.

PY - 2013/6

Y1 - 2013/6

N2 - Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.

AB - Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.

KW - Body weight changes

KW - Case-control studies

KW - Hepatoblastoma

KW - Pregnancy complications

KW - Self medication

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Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study

Abstract

Keywords

UN SDGs

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