Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones

Colin Longstaff; Imre Varjú; Péter Sótonyi; László Szabó; Michael Krumrey; Armin Hoell; Attila Bóta; Zoltán Varga; Erzsébet Komorowicz; Krasimir Kolev

doi:10.1074/jbc.M112.404301

Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones

Colin Longstaff, Imre Varjú, Péter Sótonyi, László Szabó, Michael Krumrey, Armin Hoell, Attila Bóta, Zoltán Varga, Erzsébet Komorowicz, Krasimir Kolev

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.

Original language	English (US)
Pages (from-to)	6946-6956
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M112.404301
State	Published - Mar 8 2013

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abstract = "Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.",

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AU - Longstaff, Colin

AU - Varjú, Imre

AU - Sótonyi, Péter

AU - Szabó, László

AU - Krumrey, Michael

AU - Hoell, Armin

AU - Bóta, Attila

AU - Varga, Zoltán

AU - Komorowicz, Erzsébet

AU - Kolev, Krasimir

PY - 2013/3/8

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N2 - Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.

AB - Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.

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Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones

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