Mechanism of the bisphosphatase reaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by ¹H-¹⁵N NMR spectroscopy

Medicine & Life Sciences

• phosphohistidine 100%
• Phosphofructokinase-2 85%
• Proton Magnetic Resonance Spectroscopy 62%
• Histidine 59%
• Magnetic Resonance Spectroscopy 45%
• Phosphates 27%
• Hydrogen Bonding 25%
• Hydrogen 24%
• Protons 21%
• Catalytic Domain 19%
• fructose 2,6-diphosphate 17%
• fructose-6-phosphate 16%
• Kinetics 15%
• imidazole 13%
• Mutation 12%
• Correlation of Data 11%
• Alanine 10%
• Occupations 10%
• Hydrolysis 9%
• Biochemistry 9%
• Phosphotransferases 8%
• X-Rays 8%
• Binding Sites 8%
• Phosphorylation 7%
• Water 7%
• Liver 5%

Chemical Compounds

• Histidine 50%
• NMR Spectroscopy 35%
• Mutation 22%
• Chemical Shift 21%
• Fructose 6-Phosphate 19%
• Phosphate 17%
• Proton 17%
• Hydrogen Bond 16%
• Phosphoryl 15%
• Hydrogen 13%
• Biochemistry 12%
• Kinetics Type 12%
• Imidazole 11%
• Resonance 10%
• Binding Site 9%
• Donor 9%
• Hydrolysis 8%
• Probe 8%
• Crystal Structure 6%
• Surface 4%