Metabolites of the Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone in Smokers' Urine1

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Abstract

Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 ug/24 h, respectively. The results of this study provide the first evidence for metabolites of tobacco-specific nitrosamines in human urine.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalCancer Research
Volume53
Issue number4
StatePublished - Feb 1993

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