Microdialysis in pain research

Carl Olav Stiller, Bradley K. Taylor, Bengt Linderoth, Henrik Gustafsson, Abdullahi Warsame Afrah, Ernst Brodin

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

In vivo microdialysis has been used in preclinical pain research for more than a decade. This valuable tool allows correlations between nociceptive behavior and neurotransmitter release in pain-related CNS sites. However, several methodological issues must be considered to adequately interpret microdialysis data. Thus, the aim of this review is to describe key considerations, potential pitfalls, and important control experiments. We focus on animal experiments which evaluate the effects of noxious stimulation on CNS neurotransmitter release, particularly those that address clinically relevant problems in patients with long-lasting painful conditions.

Original languageEnglish (US)
Pages (from-to)1065-1079
Number of pages15
JournalAdvanced Drug Delivery Reviews
Volume55
Issue number8
DOIs
StatePublished - Aug 15 2003

Bibliographical note

Funding Information:
Supported by NS 45954 to BKT, Swedish Science Research Council (project 6836), the Swedish Society of Medicine and the Karolinska Institutet.

Keywords

  • Animals
  • Central nervous system
  • Neurotransmitter release
  • Pain

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