We present two experiments of bioanalysis based on the self-organization of magnetic beads under a magnetic field, realized microfluidic chips, In the first one, the beads are organized in a quasi-hexagonal array of columns used as a matrix to achieve and study the separation of long fragments of DNA. In the second one, trypsin is covalently grafted onto beads that are immobilized in a microchannel, and different proteins are then digested through the bead plug. The products of digestion are then analyzed hy MS or CE.
|Translated title of the contribution||Microfluidic systems of self-assembled magnetic particles; application to DNA separation and protein digestion|
|Number of pages||4|
|State||Published - 2006|