Systèmes microfluidiques de particules magnétiques auto-assemblées; application à la séparation d'ADN et à la digestion de protéines

Translated title of the contribution: Microfluidic systems of self-assembled magnetic particles; application to DNA separation and protein digestion

Nicolas Minc, Marcela Slovakova, Kevin D. Dorfman, Claus Fütterer, Plamen Bokov, Zuzana Bilkova, Claire Smadga, Myriam Taverna, Jean Louis Viovy

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We present two experiments of bioanalysis based on the self-organization of magnetic beads under a magnetic field, realized microfluidic chips, In the first one, the beads are organized in a quasi-hexagonal array of columns used as a matrix to achieve and study the separation of long fragments of DNA. In the second one, trypsin is covalently grafted onto beads that are immobilized in a microchannel, and different proteins are then digested through the bead plug. The products of digestion are then analyzed hy MS or CE.

Translated title of the contributionMicrofluidic systems of self-assembled magnetic particles; application to DNA separation and protein digestion
Original languageFrench
Pages (from-to)51-54
Number of pages4
JournalHouille Blanche
Issue number4
DOIs
StatePublished - 2006

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