Mild cognitive impairment and dementia prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study

David S. Knopman; Rebecca F. Gottesman; Albert Richey Sharrett; Lisa M. Wruck; Beverly Gwen Windham; Laura Coker; Andrea L C Schneider; Sun Hengrui; Alvaro Alonso; Josef Coresh; Marilyn S. Albert; Thomas H. Mosley

doi:10.1016/j.dadm.2015.12.002

Mild cognitive impairment and dementia prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study

David S. Knopman, Rebecca F. Gottesman, Albert Richey Sharrett, Lisa M. Wruck, Beverly Gwen Windham, Laura Coker, Andrea L C Schneider, Sun Hengrui, Alvaro Alonso, Josef Coresh, Marilyn S. Albert, Thomas H. Mosley

Epidemiology

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Abstract

Introduction: We examined prevalence of mild cognitive impairment (MCI) and dementia in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive study. Methods: Beginning in June, 2011, we invited all surviving ARIC participants to undergo cognitive, neurologic, and brain imaging assessments to diagnose MCI or dementia and assign an etiology for the cognitive disorder. Results: Of 10,713 surviving ARIC participants (age range, 69-88 years), we ascertained cognitive diagnoses in 6471 in person, 1966 by telephone interviews (participant or informant), and the remainder by medical record review. The prevalence of dementia was 9.0% and MCI 21%. Alzheimer's disease (AD) was the primary or secondary etiology in 76% of dementia and 75% of MCI participants. Cerebrovascular disease was the primary or secondary etiology in 46% of dementia and 32% of MCI participants. Discussion: MCI and dementia were common among survivors from the original ARIC cohort. Nearly 30% of the ARIC cohort received diagnoses of either dementia or MCI, and for the majority of these individuals, the etiologic basis was attributed to AD.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	2
DOIs	https://doi.org/10.1016/j.dadm.2015.12.002
State	Published - 2016

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ). Neurocognitive data are collected by U01 HL096812, HL096814, HL096899, HL096902, and HL096917 with previous brain MRI examinations funded by R01-HL70825.

Publisher Copyright:
© 2016 The Authors.

Keywords

Alzheimer's disease
Cerebrovascular disease
Dementia
Epidemiology
Mild cognitive impairment
Prevalence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Knopman, D. S., Gottesman, R. F., Sharrett, A. R., Wruck, L. M., Windham, B. G., Coker, L., Schneider, A. L. C., Hengrui, S., Alonso, A., Coresh, J., Albert, M. S., & Mosley, T. H. (2016). Mild cognitive impairment and dementia prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2, 1-11. https://doi.org/10.1016/j.dadm.2015.12.002

Knopman, DS, Gottesman, RF, Sharrett, AR, Wruck, LM, Windham, BG, Coker, L, Schneider, ALC, Hengrui, S, Alonso, A, Coresh, J, Albert, MS & Mosley, TH 2016, 'Mild cognitive impairment and dementia prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 2, pp. 1-11. https://doi.org/10.1016/j.dadm.2015.12.002

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abstract = "Introduction: We examined prevalence of mild cognitive impairment (MCI) and dementia in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive study. Methods: Beginning in June, 2011, we invited all surviving ARIC participants to undergo cognitive, neurologic, and brain imaging assessments to diagnose MCI or dementia and assign an etiology for the cognitive disorder. Results: Of 10,713 surviving ARIC participants (age range, 69-88 years), we ascertained cognitive diagnoses in 6471 in person, 1966 by telephone interviews (participant or informant), and the remainder by medical record review. The prevalence of dementia was 9.0% and MCI 21%. Alzheimer's disease (AD) was the primary or secondary etiology in 76% of dementia and 75% of MCI participants. Cerebrovascular disease was the primary or secondary etiology in 46% of dementia and 32% of MCI participants. Discussion: MCI and dementia were common among survivors from the original ARIC cohort. Nearly 30% of the ARIC cohort received diagnoses of either dementia or MCI, and for the majority of these individuals, the etiologic basis was attributed to AD.",

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AU - Knopman, David S.

AU - Gottesman, Rebecca F.

AU - Sharrett, Albert Richey

AU - Wruck, Lisa M.

AU - Windham, Beverly Gwen

AU - Coker, Laura

AU - Schneider, Andrea L C

AU - Hengrui, Sun

AU - Alonso, Alvaro

AU - Coresh, Josef

AU - Albert, Marilyn S.

AU - Mosley, Thomas H.

N1 - Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ). Neurocognitive data are collected by U01 HL096812, HL096814, HL096899, HL096902, and HL096917 with previous brain MRI examinations funded by R01-HL70825. Publisher Copyright: © 2016 The Authors.

PY - 2016

Y1 - 2016

N2 - Introduction: We examined prevalence of mild cognitive impairment (MCI) and dementia in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive study. Methods: Beginning in June, 2011, we invited all surviving ARIC participants to undergo cognitive, neurologic, and brain imaging assessments to diagnose MCI or dementia and assign an etiology for the cognitive disorder. Results: Of 10,713 surviving ARIC participants (age range, 69-88 years), we ascertained cognitive diagnoses in 6471 in person, 1966 by telephone interviews (participant or informant), and the remainder by medical record review. The prevalence of dementia was 9.0% and MCI 21%. Alzheimer's disease (AD) was the primary or secondary etiology in 76% of dementia and 75% of MCI participants. Cerebrovascular disease was the primary or secondary etiology in 46% of dementia and 32% of MCI participants. Discussion: MCI and dementia were common among survivors from the original ARIC cohort. Nearly 30% of the ARIC cohort received diagnoses of either dementia or MCI, and for the majority of these individuals, the etiologic basis was attributed to AD.

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KW - Cerebrovascular disease

KW - Dementia

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KW - Prevalence

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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ER -

Mild cognitive impairment and dementia prevalence: The Atherosclerosis Risk in Communities Neurocognitive Study

Abstract

Bibliographical note

Keywords

UN SDGs

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