Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia

Amanda M. Termuhlen; Kathryn Klopfenstein; Randall Olshefski; Robin Rosselet; Nicholas D. Yeager; Sandeep Soni; Thomas G. Gross

doi:10.1002/pbc.21614

Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia

Amanda M. Termuhlen, Kathryn Klopfenstein, Randall Olshefski, Robin Rosselet, Nicholas D. Yeager, Sandeep Soni, Thomas G. Gross

Research output: Contribution to journal › Article › peer-review

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Abstract

Background. Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown. Procedure. Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg x 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning. Results. All five patients remain in molecular remission a median of 20 months post-transplant. Conclusion. Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation.

Original language	English (US)
Pages (from-to)	521-524
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	51
Issue number	4
DOIs	https://doi.org/10.1002/pbc.21614
State	Published - Oct 2008
Externally published	Yes

Keywords

APL
Autologous stem cell transplant
Pediatric
Relapsed

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Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia. / Termuhlen, Amanda M.; Klopfenstein, Kathryn; Olshefski, Randall et al.
In: Pediatric Blood and Cancer, Vol. 51, No. 4, 10.2008, p. 521-524.

Research output: Contribution to journal › Article › peer-review

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title = "Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia",

abstract = "Background. Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown. Procedure. Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg x 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning. Results. All five patients remain in molecular remission a median of 20 months post-transplant. Conclusion. Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation.",

keywords = "APL, Autologous stem cell transplant, Pediatric, Relapsed",

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T1 - Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia

AU - Termuhlen, Amanda M.

AU - Klopfenstein, Kathryn

AU - Olshefski, Randall

AU - Rosselet, Robin

AU - Yeager, Nicholas D.

AU - Soni, Sandeep

AU - Gross, Thomas G.

PY - 2008/10

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N2 - Background. Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown. Procedure. Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg x 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning. Results. All five patients remain in molecular remission a median of 20 months post-transplant. Conclusion. Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation.

AB - Background. Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown. Procedure. Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg x 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning. Results. All five patients remain in molecular remission a median of 20 months post-transplant. Conclusion. Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation.

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KW - Pediatric

KW - Relapsed

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Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia

Abstract

Keywords

UN SDGs

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