Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia

Amanda M. Termuhlen, Kathryn Klopfenstein, Randall Olshefski, Robin Rosselet, Nicholas D. Yeager, Sandeep Soni, Thomas G. Gross

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background. Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown. Procedure. Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg x 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning. Results. All five patients remain in molecular remission a median of 20 months post-transplant. Conclusion. Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalPediatric Blood and Cancer
Volume51
Issue number4
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • APL
  • Autologous stem cell transplant
  • Pediatric
  • Relapsed

Fingerprint Dive into the research topics of 'Mobilization of PML-RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocyte leukemia'. Together they form a unique fingerprint.

Cite this