Molecular genetics of myeloma

Brian Van Ness

doi:10.1007/978-1-4614-3764-2_31

Molecular genetics of myeloma

Brian Van Ness

Genetics, Cell Biology and Development (TMED)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.

Original language	English (US)
Title of host publication	Neoplastic Diseases of the Blood
Publisher	Springer New York
Pages	601-613
Number of pages	13
ISBN (Electronic)	9781461437642
ISBN (Print)	1461437636, 9781461437635
DOIs	https://doi.org/10.1007/978-1-4614-3764-2_31
State	Published - Nov 1 2013

Bibliographical note

Publisher Copyright:
© 2013 Springer Science+Business Media New York. All rights reserved.

Keywords

Microarray gene expression
Multiple myeloma
Primary and secondary genetic events
Single-nucleotide polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1007/978-1-4614-3764-2_31

OpenUrl availability

Full text

Cite this

@inbook{9701fc7044dc47edbff93a7afe58e2b1,

title = "Molecular genetics of myeloma",

abstract = "Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.",

keywords = "Microarray gene expression, Multiple myeloma, Primary and secondary genetic events, Single-nucleotide polymorphism",

author = "{Van Ness}, Brian",

year = "2013",

month = nov,

day = "1",

doi = "10.1007/978-1-4614-3764-2_31",

language = "English (US)",

isbn = "1461437636",

pages = "601--613",

booktitle = "Neoplastic Diseases of the Blood",

publisher = "Springer New York",

}

TY - CHAP

T1 - Molecular genetics of myeloma

AU - Van Ness, Brian

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.

AB - Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.

KW - Microarray gene expression

KW - Multiple myeloma

KW - Primary and secondary genetic events

KW - Single-nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84929543074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929543074&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-3764-2_31

DO - 10.1007/978-1-4614-3764-2_31

M3 - Chapter

AN - SCOPUS:84929543074

SN - 1461437636

SN - 9781461437635

SP - 601

EP - 613

BT - Neoplastic Diseases of the Blood

PB - Springer New York

ER -

Molecular genetics of myeloma

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this