Morphine negatively regulates interferon-γ promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways

Medicine & Life Sciences

• Cyclic AMP 83%
• Morphine 79%
• Interferons 77%
• T-Lymphocytes 52%
• Opioid Receptors 20%
• p38 Mitogen-Activated Protein Kinases 18%
• Bucladesine 15%
• Transcription Factor AP-1 13%
• Colforsin 13%
• Knockout Mice 11%
• NFATC Transcription Factors 8%
• SB 203580 7%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7%
• Pertussis Toxin 6%
• MAP Kinase Signaling System 6%
• Protein Kinase Inhibitors 6%
• Cyclic AMP-Dependent Protein Kinases 6%
• HIV Infections 5%
• Transcription Factors 4%
• Phosphorylation 4%
• Incidence 2%

Chemical Compounds

• Morphine 100%
• Forskolin 17%
• Cyclic Amp Dependent Protein Kinase Inhibitor 11%
• Toxin 5%
• Additive 4%