Multicomponent syntheses of 5- And 6-membered aromatic heterocycles using group 4-8 transition metal catalysts

Daniel N. Huh, Yukun Cheng, Connor W. Frye, Dominic T. Egger, Ian A. Tonks

Research output: Contribution to journalArticlepeer-review

Abstract

In thisPerspective, we discuss recent syntheses of 5- and 6-membered aromatic heterocyclesviamulticomponent reactions (MCRs) that are catalyzed by group 4-8 transition metals. These MCRs can be categorized based on the substrate components used to generate the cyclized product, as well as on common mechanistic features between the catalyst systems. These particular groupings are intended to highlight mechanistic and strategic similarities between otherwise disparate transition metals and to encourage future work exploring related systems with otherwise-overlooked elements. Importantly, in many cases these early- to mid-transition metal catalysts have been shown to be as effective for heterocycle syntheses as the later (and more commonly implemented) group 9-11 metals.

Original languageEnglish (US)
Pages (from-to)9574-9590
Number of pages17
JournalChemical Science
Volume12
Issue number28
DOIs
StatePublished - Jul 28 2021

Bibliographical note

Funding Information:
Financial support was provided by the National Institutes of Health (R35GM119457, F32GM137547 to D. N. H.). Y. C. is supported by a University of Minnesota Wayland E. Noland Fellowship. D. T. E. kindly acknowledges financial support from the ETH Z?rich Foundation (D. T. E. is a 2019 ESOP scholar).

Funding Information:
Financial support was provided by the National Institutes of Health (R35GM119457, F32GM137547 to D. N. H.). Y. C. is supported by a University of Minnesota Wayland E. Noland Fellowship. D. T. E. kindly acknowledges nancial support from the ETH Zürich Foundation (D. T. E. is a 2019 ESOP scholar).

Publisher Copyright:
© The Royal Society of Chemistry 2021.

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