Multifunctional deadenylase complexes diversify mRNA control

Aaron C. Goldstrohm; Marvin Wickens

doi:10.1038/nrm2370

Multifunctional deadenylase complexes diversify mRNA control

Aaron C. Goldstrohm, Marvin Wickens

Research output: Contribution to journal › Comment/debate › peer-review

324 Scopus citations

Abstract

Dynamic changes of the lengths of mRNA poly(A) tails are catalysed by diverse deadenylase enzymes. Modulating the length of the poly(A) tail of an mRNA is a widespread means of controlling protein production and mRNA stability. Recent insights illuminate the specialized activities, biological functions and regulation of deadenylases. We propose that the recruitment of multifunctional deadenylase complexes provides unique opportunities to control mRNAs and that the heterogeneity of the deadenylase complexes is exploited to control translation and mRNA stability.

Original language	English (US)
Pages (from-to)	337-344
Number of pages	8
Journal	Nature Reviews Molecular Cell Biology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/nrm2370
State	Published - Apr 2008
Externally published	Yes

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Multifunctional deadenylase complexes diversify mRNA control

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