TY - JOUR
T1 - Multimodal Functional Neuroimaging
T2 - Integrating Functional MRI and EEG/MEG
AU - He, Bin
AU - Liu, Zhongming
PY - 2008
Y1 - 2008
N2 - Noninvasive functional neuroimaging, as an important tool for basic neuroscience research and clinical diagnosis, continues to face the need of improving the spatial and temporal resolution. While existing neuroimaging modalities might approach their limits in imaging capability mostly due to fundamental as well as technical reasons, it becomes increasingly attractive to integrate multiple complementary modalities in an attempt to significantly enhance the spatiotemporal resolution that cannot be achieved by any modality individually. Electrophysiological and hemodynamic/metabolic signals reflect distinct but closely coupled aspects of the underlying neural activity. Combining fMRI and EEG/MEG data allows us to study brain function from different perspectives. In this review, we start with an overview of the physiological origins of EEG/MEG and fMRI, as well as their fundamental biophysics and imaging principles, we proceed with a review of the major advances in the understanding and modeling of neurovascular coupling and in the methodologies for the fMRI-EEG/MEG simultaneous recording. Finally, we summarize important remaining issues and perspectives concerning multimodal functional neuroimaging, including brain connectivity imaging.
AB - Noninvasive functional neuroimaging, as an important tool for basic neuroscience research and clinical diagnosis, continues to face the need of improving the spatial and temporal resolution. While existing neuroimaging modalities might approach their limits in imaging capability mostly due to fundamental as well as technical reasons, it becomes increasingly attractive to integrate multiple complementary modalities in an attempt to significantly enhance the spatiotemporal resolution that cannot be achieved by any modality individually. Electrophysiological and hemodynamic/metabolic signals reflect distinct but closely coupled aspects of the underlying neural activity. Combining fMRI and EEG/MEG data allows us to study brain function from different perspectives. In this review, we start with an overview of the physiological origins of EEG/MEG and fMRI, as well as their fundamental biophysics and imaging principles, we proceed with a review of the major advances in the understanding and modeling of neurovascular coupling and in the methodologies for the fMRI-EEG/MEG simultaneous recording. Finally, we summarize important remaining issues and perspectives concerning multimodal functional neuroimaging, including brain connectivity imaging.
KW - EEG
KW - MEG
KW - fMRI
KW - human brain mapping
KW - multimodal neuroimaging
KW - neurovascular coupling
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U2 - 10.1109/RBME.2008.2008233
DO - 10.1109/RBME.2008.2008233
M3 - Article
C2 - 20634915
AN - SCOPUS:65249142211
SN - 1937-3333
VL - 1
SP - 23
EP - 40
JO - IEEE Reviews in Biomedical Engineering
JF - IEEE Reviews in Biomedical Engineering
ER -